![]() ![]() They can both be used with traditional and high-flow media families, such as Capto and MabSelect. Media compatibility and system connectivity AxiChrom columns are developed for use with a wide range of medium types. Quick to fit, they also add extra convenience when changing to new campaigns in multipurpose facilities. Single-use, low-cost plastic bed supports are ideal for processes that risk corroding metal column parts. Table 2 lists the general chemical resistance of AxiChrom columns. Construction materials in AxiChrom columns (Table ) are resistant to most chemical agents used in chromatography, including buffer solutions for adsorption, elution and washing, and to solutions effective in cleaning, sanitization, and storage. 2) can be fitted for such a purpose, or as a low-cost, single-use bed support for multipurpose facilities. For potentially corrosive processes, an available configuration of the standard platform is columns with all nonmetallic wetted flow-paths. Pressure-retaining and wetted parts are traceable to batch level and the materials are certificated according to EN for steel parts and 2. Our manufacturing processes are also free from animal-derived ingredients. The materials are free from animal-derived components or in compliance with EMA/40/0 Rev.2. Wetted polymeric materials and elastomers meet the requirements of USP Class VI as described in USP Biological Reactivity Tests In Vivo and 2 CFR Part 77, issued from the FDA. Ģ Materials of construction Materials of construction are recognized for use in biopharmaceutical manufacture and fulfill the ASME Bioprocessing Equipment Standard. The unit also offers support for other parts of the process, for example, simple step-by-step maintenance guides, which reduces risks for operator errors. Control of the media valve and adapter is done via the AxiChrom Master. The adapter is driven by an electric servomotor. In AxiChrom 300 to 600 columns, slurry is introduced via a media valve in the center of the bottom bed support. When packing AxiChrom 50 to 200 columns, slurry is introduced by hand and adapter movement is driven by internal hydraulics. For AxiChrom 300 to 600, Intelligent packing is available through the separate AxiChrom Master unit. It is part of the UNICORN software for use with ÄKTA protein purification systems. Intelligent packing supports all column sizes. ![]() Automated methods brings several benefits, for example, minimized hands-on time and excellent reproducibility. ![]() It enables creation of automated methods for packing, unpacking, priming, and maintenance. Handling AxiChrom columns is easy using Intelligent packing. A selection of columns from the AxiChrom platform. The swing-out function is an example of how the design enables a significant reduction in handling time, compared to other column series. In larger columns, 300 to 600 mm i.d., the tube swings out allowing hoist-free handling. The smaller columns, 50 to 200 mm i.d., have a stand with a pivot design. All have a thoughtful design for easy handling and maintenance. A range of column sizes is available, from 50 to 600 mm inner diameter (i.d.). It is also a great solution for manufacturing networks in need for a robust and standardized column solution. This attribute, in combination with automated packing and easy maintenance, make the platform an excellent choice for multipurpose facilities. It enables many configuration possibilities that can fit different needs. AxiChrom is a configurable yet standardized platform. They are excellent for use during process development and manufacturing of biopharmaceutical products. AxiChrom columns are: intelligent: reduced operation time through automation, verified methods, and simplified workflows intuitive: increased uptime through simple design with reduced risk for operator errors predictable: quick and easy technology-transfer through scalable and robust platform design Column description General AxiChrom columns are low-pressure, axial compression chromatography columns. Excellent compatibility of chromatography columns, media, and systems enables reliable results and high productivity. This includes traditional BioProcess media, such as the Sepharose family, as well as high-flow media families, like Capto and MabSelect. The entire AxiChrom column line has been designed and verified to give exceptional performance with a broad range of media (resins). Compared to a conventional column, AxiChrom columns purposeful design makes process chromatography easier, safer, and more efficient. It simplifies column handling at all scales, from pilot to large-scale production. ![]() 1 AxiChrom columns CHROMATOGRAPHY COLUMNS The AxiChrom column platform (Fig ) is a revolutionary concept in column chromatography. ![]()
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